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Recombinant mouse nerve growth factor

Analyse Recombinant mouse nerve growth factor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5LSD
Type: protein
Length: 236 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-nerve growth factor
UniProt: P01139
Pockets: 1 · best druggability 0.59

Structure

solution nmr · 1 distinct chain · 3% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Beta-nerve growth factor	protein	118	3% helix, 54% strand	P01139

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	312	0.59	0.78	48	empty

Interfaces

1 interface between chains.

A–B · 1699 Å² buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

5LSD · recombinant mouse Nerve Growth Factor · the same entry in another collection · chain A against A, TM-score 1.00
P01139 · AlphaFold monomer V2.0 prediction for beta-nerve growth factor (P01139) · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01139
Elsewhere: RCSB PDB 5LSD · PDBe 5LSD · UniProt P01139

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