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Structure of the H959F variant of the ppsc dehydratase domain from mycobacterium tuberculosis

Analyse Structure of the H959F variant of the ppsc dehydratase domain from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5L84
Type: protein
Length: 269 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phthiocerol synthesis polyketide synthase type I ppsc
EC: 2.3.1.41
UniProt: P96202
Pockets: 1 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 20% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phthiocerol synthesis polyketide synthase type I ppsc (EC 2.3.1.41)	protein	269	20% helix, 41% strand	P96202

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	175	0.73	0.90	40	empty

Compared structures

5L84 · Structure of the H959F variant of the PpsC dehydratase domain from Mycobacterium… · the same entry in another collection · chain A against A, TM-score 1.00
P96202 · AlphaFold monomer V2.0 prediction for PHENOLPHTHIOCEROL/PHTHIOCEROL polyketide synthase… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P96202
Elsewhere: RCSB PDB 5L84 · PDBe 5L84 · UniProt P96202

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