UBA1 in complex with ub-MLN7243 covalent adduct

Structure

x-ray diffraction · 3 distinct chains.

Ligands and binding sites

• 61T · [(1~{R},2~{R},3~{S},4~{R})-2,3-bis(oxidanyl)-4-[[2-[3-(trifluoromethylsulfanyl)phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl sulfamate · ligand · 2 copies · chains A, B, C, D
• CL · Chloride ion · ion · 4 copies · chains A, C
• SO4 · Sulfate ion · ion · 3 copies · chains A, C
• GOL · Glycerol · additive · 16 copies · chains A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5L6J · Uba1 in complex with Ub-MLN7243 covalent adduct · the same entry in another collection · chain A against A, TM-score 1.00
• P22515 · AlphaFold monomer V2.0 prediction for ubiquitin-activating enzyme E1 1 (P22515) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P22515
• Every structure of UniProt P05759
• Elsewhere: RCSB PDB 5L6J · PDBe 5L6J · UniProt P22515 · UniProt P05759