UniProt P22515
Ubiquitin-activating enzyme E1 1 (P22515)
Ubiquitin-activating enzyme E1 1 (UniProt P22515), EC 6.2.1.45: 25 experimental structures on GenesisL1, 9 ligands bound, 132 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P22515
- Protein
- Ubiquitin-activating enzyme E1 1
- EC
- 6.2.1.45
- Experimental structures
- 25
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 132 · 7 records with a druggable one
Structures
25 records of P22515 in the MolNFT archive: 25 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3CMM | Crystal Structure of the Uba1-Ubiquitin Complex | x-ray diffraction | A, C | — | — |
| 3CMM | Crystal structure of the UBA1-ubiquitin complex | x-ray diffraction | A, C | — | — |
| 4NNJ | Crystal structure of Uba1 in complex with ubiquitin-AMP and thioesterified ubiquitin | x-ray diffraction | A, C | — | — |
| 4NNJ | Crystal structure of UBA1 in complex with ubiquitin-AMP and thioesterified ubiquitin | x-ray diffraction | A, C | — | — |
| 5L6H | Uba1 in complex with Ub-ABPA3 covalent adduct | x-ray diffraction | A, C | SO4, CL, 6O2, MG | — |
| 5L6H | UBA1 in complex with ub-ABPA3 covalent adduct | x-ray diffraction | A, C | SO4, CL, 6O2, MG | — |
| 5L6I | Uba1 in complex with Ub-MLN4924 covalent adduct | x-ray diffraction | A, C | SO4, CL, B39 | — |
| 5L6I | UBA1 in complex with ub-MLN4924 covalent adduct | x-ray diffraction | A, C | SO4, CL, B39 | — |
| 5L6J | Uba1 in complex with Ub-MLN7243 covalent adduct | x-ray diffraction | A, C | SO4, CL, 61T | 20 (best 0.74) |
| 5L6J | UBA1 in complex with ub-MLN7243 covalent adduct | x-ray diffraction | A, C | SO4, CL, 61T | — |
| 5TR4 | Structure of Ubiquitin activating enzyme (Uba1) in complex with ubiquitin and TAK-243 | x-ray diffraction | A, C | 61T | 20 (best 0.78) |
| 5TR4 | Structure of ubiquitin activating enzyme (UBA1) in complex with ubiquitin and tak-243 | x-ray diffraction | A, C | 61T | — |
| 6NYA | Crystal structure of ubiquitin E1 (UBA1) in complex with UBC3 (CDC34) and ubiquitin | x-ray diffraction | A, D | ATP, MG, SO4 | — |
| 6ZHS | Uba1 bound to two E2 (Ubc13) molecules | x-ray diffraction | A | SO4 | 19 (best 0.84) |
| 6ZHS | UBA1 bound to two E2 (UBC13) molecules | x-ray diffraction | A | SO4 | — |
| 6ZHT | Uba1-Ubc13 disulfide mediated complex | x-ray diffraction | C | CL | 13 (best 0.79) |
| 6ZHT | UBA1-UBC13 disulfide mediated complex | x-ray diffraction | C | CL | — |
| 6ZHU | Yeast Uba1 in complex with Ubc3 and ATP | x-ray diffraction | A, E, C, G | ATP, MG | 20 (best 0.83) |
| 6ZHU | Yeast UBA1 in complex with UBC3 and ATP | x-ray diffraction | A, E, C, G | ATP, MG | — |
| 6ZQH | Yeast Uba1 in complex with ubiquitin | x-ray diffraction | A, C | — | 20 (best 0.69) |
| 6ZQH | Yeast UBA1 in complex with ubiquitin | x-ray diffraction | A, C | — | — |
| 7K5J | Structure of an E1-E2-ubiquitin thioester mimetic | x-ray diffraction | D, A, C, G, I, K, S, U | AMP | 20 (best 0.82) |
| 7K5J | Structure of an E1-E2-ubiquitin thioester mimetic | x-ray diffraction | D, A, C, G, I, K, S, U | AMP | — |
| 7ZH9 | UBA1 in complex with ATP | x-ray diffraction | A | ATP, SO4, MG, K, CL | — |
| P22515 | AlphaFold monomer V2.0 prediction for ubiquitin-activating enzyme E1 1 (P22515) | — | — | — |
Ligands
- SO4 · Sulfate ion · in 10 records
- CL · Chloride ion · in 9 records
- MG · Magnesium ion · in 6 records
- 61T · [(1~{R},2~{R},3~{S},4~{R})-2,3-bis(oxidanyl)-4-[[2-[3-(trifluoromethylsulfanyl)phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]methyl sulfamate · in 4 records
- ATP · Adenosine-5'-triphosphate · in 4 records
- 6O2 · [(2~{R},3~{S},4~{R},5~{R})-5-[6-[(3-ethynylphenyl) amino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl sulfamate · in 2 records
- AMP · Adenosine monophosphate · in 2 records
- B39 · [(1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate · in 2 records
- K · Potassium ion · in 1 record
Elsewhere
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