Research workbench
Structure of interferon lambda 1 receptor with human kinase JAK1
Analyse Structure of interferon lambda 1 receptor with human kinase JAK1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5L04
- Type
- protein
- Length
- 497 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase JAK1; Interferon lambda receptor 1
- EC
- 2.7.10.2
- UniProt
- P23458, Q8IU57
- Pockets
- 7 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase JAK1 (EC 2.7.10.2) | protein | 460 | 36% helix, 26% strand | P23458 |
| B | Interferon lambda receptor 1 | protein | 37 | 8% helix, 16% strand | Q8IU57 |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 433 | 0.79 | 0.87 | 53 | empty |
| 2 | 280 | 0.64 | 0.81 | 28 | empty |
| 3 | 379 | 0.61 | 0.77 | 50 | empty |
| 4 | 208 | 0.54 | 0.78 | 38 | empty |
| 5 | 227 | 0.51 | 0.76 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 1777 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 5L04 · Structure of interferon lambda 1 receptor with human kinase JAK1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8IU57 · AlphaFold monomer V2.0 prediction for interferon lambda receptor 1 (Q8IU57) · a predicted model of the same protein · chain B against A, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23458
- Every structure of UniProt Q8IU57
- Elsewhere: RCSB PDB 5L04 · PDBe 5L04 · UniProt P23458 · UniProt Q8IU57
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