Research workbench
Expanded poliovirus in complex with vhh 17B
Analyse Expanded poliovirus in complex with vhh 17B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5KU0
- Type
- protein
- Length
- 806 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- VP1; VP2; VP3; Vhh 17B
- UniProt
- P03300
- Pockets
- 8 · best druggability 0.70
Structure
electron microscopy · 4 distinct chains · 10% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 1 | VP1 | protein | 205 | 11% helix, 35% strand | P03300 |
| 2 | VP2 | protein | 246 | 12% helix, 32% strand | P03300 |
| 3 | VP3 | protein | 231 | 9% helix, 27% strand | P03300 |
| 7 | Vhh 17B | protein | 124 | 5% helix, 35% strand | — |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 280 | 0.70 | 0.85 | 50 | empty |
| 2 | 55 | 0.62 | 0.93 | 19 | empty |
| 3 | 223 | 0.57 | 0.79 | 25 | empty |
| 4 | 344 | 0.55 | 0.74 | 43 | empty |
| 5 | 235 | 0.50 | 0.75 | 37 | empty |
Interfaces
4 interfaces between chains.
- 1–3 · 2789 Ų buried · 34 hydrogen bonds · protein-protein
- 2–3 · 1847 Ų buried · 24 hydrogen bonds · protein-protein
- 1–2 · 1284 Ų buried · 11 hydrogen bonds · protein-protein
- 3–7 · 1076 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5KU0 · expanded poliovirus in complex with VHH 17B · the same entry in another collection · chain 7 against 7, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03300
- Elsewhere: RCSB PDB 5KU0 · PDBe 5KU0 · UniProt P03300
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.