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Recombinant bovine skeletal calsequestrin, high-CA2+ form

Analyse Recombinant bovine skeletal calsequestrin, high-CA2+ form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5KN1
Type: protein
Length: 1,042 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calsequestrin
UniProt: Q05JF3
Ligands: CA, CL
Pockets: 18 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calsequestrin	protein	346	41% helix, 20% strand	Q05JF3
B, C	Calsequestrin	protein	348	40% helix, 19% strand	Q05JF3

Ligands and binding sites

CA · Calcium ion · metal · 40 copies · chains A, B, C
CL · Chloride ion · ion · chains B
MPD · (4S)-2-methyl-2,4-pentanediol · additive · 4 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

18 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	534	0.82	0.88	56	empty
2	1055	0.78	0.79	72	CA
3	262	0.75	0.89	35	empty
4	342	0.71	0.84	28	empty
5	354	0.69	0.82	30	empty

Interfaces

2 interfaces between chains.

B–C · 2420 Å² buried · 23 hydrogen bonds · protein-protein
A–B · 481 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

5KN1 · Recombinant bovine skeletal calsequestrin, high-Ca2+ form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q05JF3
Elsewhere: RCSB PDB 5KN1 · PDBe 5KN1 · UniProt Q05JF3

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