Research workbench
Structure of human islet amyloid polypeptide in complex with an engineered binding protein
Analyse Structure of human islet amyloid polypeptide in complex with an engineered… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5K5G
- Type
- protein
- Length
- 109 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Islet amyloid polypeptide; HI18
- UniProt
- P10997
- Pockets
- 1 · best druggability 0.51
Structure
solution nmr · 2 distinct chains · 46% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Islet amyloid polypeptide | protein | 21 | 0% helix, 62% strand | P10997 |
| B, C | HI18 | protein | 44 | 68% helix, 7% strand | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.51 | 0.82 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–C · 659 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 558 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 378 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5K5G · Structure of human islet amyloid polypeptide in complex with an engineered binding protein · the same entry in another collection · chain A against A, TM-score 1.00
- P10997 · AlphaFold monomer V2.0 prediction for islet amyloid polypeptide (P10997) · a predicted model of the same protein · chain A against A, TM-score 0.18
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10997
- Elsewhere: RCSB PDB 5K5G · PDBe 5K5G · UniProt P10997
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.