Research workbench
EIF3B relocated to the intersubunit face to interact with EIF1 and below the EIF2 ternary-complex. from the structure of a partial yeast 48S preinitiation complex in closed conformation.
Analyse EIF3B relocated to the intersubunit face to interact with EIF1 and below the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5K1H
- Type
- protein
- Length
- 608 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 3 subunit B; EIF3A C-terminal tail
- UniProt
- P55884
- Pockets
- 5 · best druggability 0.63
Structure
electron microscopy · 2 distinct chains · 17% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Eukaryotic translation initiation factor 3 subunit B | protein | 554 | 10% helix, 41% strand | P55884 |
| A | EIF3A C-terminal tail | protein | 54 | 91% helix, 0% strand | — |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 663 | 0.63 | 0.73 | 55 | empty |
| 2 | 168 | 0.53 | 0.79 | 22 | empty |
| 3 | 55 | 0.35 | 0.78 | 16 | empty |
| 4 | 51 | 0.33 | 0.78 | 19 | empty |
| 5 | 63 | 0.30 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- B–A · 579 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 5K1H · eIF3b relocated to the intersubunit face to interact with eIF1 and below the eIF2… · the same entry in another collection · chain A against A, TM-score 1.00
- P55884 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain B against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55884
- Elsewhere: RCSB PDB 5K1H · PDBe 5K1H · UniProt P55884
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