Research workbench

Psd-95 extended PDZ3 in complex with syngap pbm

Analyse Psd-95 extended PDZ3 in complex with syngap pbm in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5JXB
Type: protein
Length: 236 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Disks large homolog 4,SYNGAP
UniProt: P78352
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 27% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Disks large homolog 4,SYNGAP	protein	117	24% helix, 29% strand	P78352
C	Disks large homolog 4,SYNGAP	protein	119	30% helix, 26% strand	P78352

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	285	0.65	0.81	28	empty
2	67	0.31	0.74	19	empty

Interfaces

1 interface between chains.

A–C · 494 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

5JXB · PSD-95 extended PDZ3 in complex with SynGAP PBM · the same entry in another collection · chain A against A, TM-score 1.00
P78352 · AlphaFold monomer V2.0 prediction for disks large homolog 4 (P78352) · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P78352
Elsewhere: RCSB PDB 5JXB · PDBe 5JXB · UniProt P78352

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