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Crystal structure of the human tankyrase 1 (tnks) SAM domain (D1055R), crystal form 1
Analyse Crystal structure of the human tankyrase 1 (tnks) SAM domain (D1055R), crystal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5JU5
- Type
- protein
- Length
- 366 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tankyrase-1
- EC
- 2.4.2.30
- UniProt
- O95271
- Pockets
- 3 · best druggability 0.46
Structure
x-ray diffraction · 5 distinct chains · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tankyrase-1 (EC 2.4.2.30) | protein | 60 | 70% helix, 0% strand | O95271 |
| B, E | Tankyrase-1 (EC 2.4.2.30) | protein | 59 | 68% helix, 0% strand | O95271 |
| C | Tankyrase-1 (EC 2.4.2.30) | protein | 66 | 65% helix, 0% strand | O95271 |
| D | Tankyrase-1 (EC 2.4.2.30) | protein | 61 | 69% helix, 0% strand | O95271 |
| F | Tankyrase-1 (EC 2.4.2.30) | protein | 61 | 70% helix, 0% strand | O95271 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.46 | 0.80 | 21 | empty |
| 2 | 90 | 0.40 | 0.77 | 16 | empty |
| 3 | 93 | 0.35 | 0.75 | 22 | empty |
Interfaces
6 interfaces between chains.
- A–D · 427 Ų buried · 8 hydrogen bonds · protein-protein
- D–E · 385 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 367 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 365 Ų buried · 4 hydrogen bonds · protein-protein
- D–F · 353 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5JU5 · Crystal structure of the human Tankyrase 1 (TNKS) SAM domain (D1055R), crystal form 1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95271
- Elsewhere: RCSB PDB 5JU5 · PDBe 5JU5 · UniProt O95271
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