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Structure of the NS3 helicase from the french polynesia strain of the zika virus

Analyse Structure of the NS3 helicase from the french polynesia strain of the zika virus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5JRZ
Type: protein
Length: 443 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Helicase
Ligands: POP
Pockets: 3 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Helicase	protein	443	34% helix, 19% strand	—

Ligands and binding sites

POP · Pyrophosphate 2- · ligand · chains A
ACT · Acetate ion · additive · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	962	0.76	0.79	83	ACT
2	128	0.56	0.83	25	POP
3	52	0.32	0.77	15	empty

Compared structures

5JRZ · Structure of the NS3 helicase from the French Polynesia strain of the Zika virus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 5JRZ · PDBe 5JRZ

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