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Crystal structure of CASPASE8 tded

Analyse Crystal structure of CASPASE8 tded in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5JQE
Type: protein
Length: 544 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sugar ABC transporter substrate-binding PROTEIN,CASPASE-8 chimera
EC: 3.4.22.61
UniProt: A0A0L7A8Z3, Q14790
Pockets: 3 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 50% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sugar ABC transporter substrate-binding PROTEIN,CASPASE-8 chimera (EC 3.4.22.61)	protein	544	50% helix, 14% strand	A0A0L7A8Z3, Q14790

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	601	0.68	0.77	86	empty
2	93	0.38	0.76	15	empty
3	60	0.29	0.74	15	empty

Compared structures

5JQE · Crystal structure of caspase8 tDED · the same entry in another collection · chain A against A, TM-score 1.00
Q14790 · AlphaFold monomer V2.0 prediction for caspase-8 (Q14790) · a predicted model of the same protein · chain A against A, TM-score 0.33

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0L7A8Z3
Every structure of UniProt Q14790
Elsewhere: RCSB PDB 5JQE · PDBe 5JQE · UniProt A0A0L7A8Z3 · UniProt Q14790

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