Research workbench
Crystal structure of CSN5(2-257) in complex with CNS5I-3
Analyse Crystal structure of CSN5(2-257) in complex with CNS5I-3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5JOG
- Type
- protein
- Length
- 221 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- COP9 signalosome complex subunit 5
- EC
- 3.4.-.-
- UniProt
- Q92905
- Ligands
- 6LT, ZN
- Pockets
- 4 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | COP9 signalosome complex subunit 5 (EC 3.4.-.-) | protein | 221 | 42% helix, 23% strand | Q92905 |
Ligands and binding sites
- 6LT · 3-(difluoromethyl)-N-{6-[(5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-yl}-1-(propan-2-yl)-1H-pyrazole-5-carboxamide · ligand · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.54 | 0.76 | 31 | empty |
| 2 | 187 | 0.48 | 0.75 | 34 | empty |
| 3 | 56 | 0.36 | 0.79 | 14 | empty |
| 4 | 79 | 0.33 | 0.74 | 16 | empty |
Compared structures
- 5JOG · CRYSTAL STRUCTURE OF CSN5(2-257) IN COMPLEX WITH CNS5i-3 · the same entry in another collection · chain A against A, TM-score 1.00
- Q92905 · AlphaFold monomer V2.0 prediction for COP9 signalosome complex subunit 5 (Q92905) · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92905
- Elsewhere: RCSB PDB 5JOG · PDBe 5JOG · UniProt Q92905
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