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Crystal structure of bovine low molecular weight protein tyrosine phosphatase (lmptp) mutant (W49Y N50E) complexed with vanadate and uncompetitive inhibitor

Analyse Crystal structure of bovine low molecular weight protein tyrosine phosphatase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5JNW
Type: protein
Length: 154 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Low molecular weight phosphotyrosine protein phosphatase
EC: 3.1.3.48
UniProt: P11064
Ligands: 6LJ, VO4

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Low molecular weight phosphotyrosine protein phosphatase (EC 3.1.3.48)	protein	154	45% helix, 15% strand	P11064

Ligands and binding sites

6LJ · 2-(4-{[3-(piperidin-1-yl)propyl]amino}quinolin-2-yl)benzonitrile · ligand · chains A
VO4 · Vanadate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5JNW · Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP)… · the same entry in another collection · chain A against A, TM-score 1.00
P11064 · AlphaFold monomer V2.0 prediction for low molecular weight phosphotyrosine protein… · a predicted model of the same protein · chain A against A, TM-score 0.99

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11064
Elsewhere: RCSB PDB 5JNW · PDBe 5JNW · UniProt P11064

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