Research workbench
Crystal structure of the hat domain of SART3 in complex with USP15 dusp-ubl domain
Analyse Crystal structure of the hat domain of SART3 in complex with USP15 dusp-ubl… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5JJW
- Type
- protein
- Length
- 445 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Squamous cell carcinoma antigen recognized by T-cells 3; Ubiquitin carboxyl-terminal…
- EC
- 3.4.19.12
- UniProt
- Q15020, Q9Y4E8
- Ligands
- UNX
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Squamous cell carcinoma antigen recognized by T-cells 3 | protein | 296 | 79% helix, 0% strand | Q15020 |
| B | Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) | protein | 149 | 31% helix, 18% strand | Q9Y4E8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 902 | 0.70 | 0.75 | 76 | empty |
| 2 | 146 | 0.59 | 0.83 | 29 | empty |
| 3 | 52 | 0.24 | 0.72 | 8 | empty |
Interfaces
1 interface between chains.
- A–B · 620 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 modified (engineered).
Compared structures
- 5JJW · Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q15020 · AlphaFold monomer V2.0 prediction for squamous cell carcinoma antigen recognized by… · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9Y4E8 · AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 15 (Q9Y4E8) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15020
- Every structure of UniProt Q9Y4E8
- Elsewhere: RCSB PDB 5JJW · PDBe 5JJW · UniProt Q15020 · UniProt Q9Y4E8
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