Research workbench
Structure of disulfide crosslinked a. fumigatus FKBP12(V91C)
Analyse Structure of disulfide crosslinked a. fumigatus FKBP12(V91C) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5J6E
- Type
- protein
- Length
- 222 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- FK506-binding protein 1A
- EC
- 5.2.1.8
- UniProt
- Q4WLV6
- Pockets
- 4 · best druggability 0.45
Structure
x-ray diffraction · 1 distinct chain · 17% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | FK506-binding protein 1A (EC 5.2.1.8) | protein | 111 | 17% helix, 36% strand | Q4WLV6 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.45 | 0.81 | 14 | empty |
| 2 | 57 | 0.39 | 0.79 | 17 | empty |
| 3 | 78 | 0.34 | 0.75 | 20 | empty |
| 4 | 58 | 0.32 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 348 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4WLV6
- Elsewhere: RCSB PDB 5J6E · PDBe 5J6E · UniProt Q4WLV6
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