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Hantaan virus L protein cap-snatching endonuclease

Analyse Hantaan virus L protein cap-snatching endonuclease in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5IZE
Type: protein
Length: 349 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed RNA polymerase L
EC: 2.7.7.48
UniProt: P23456
Ligands: MN3
Pockets: 1 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 49% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-directed RNA polymerase L (EC 2.7.7.48)	protein	180	48% helix, 18% strand	P23456
B	RNA-directed RNA polymerase L (EC 2.7.7.48)	protein	169	51% helix, 17% strand	P23456

Ligands and binding sites

MN3 · Manganese (III) ion · metal · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	424	0.58	0.74	55	empty

Interfaces

1 interface between chains.

A–B · 283 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

5IZE · Hantaan virus L protein cap-snatching endonuclease · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23456
Elsewhere: RCSB PDB 5IZE · PDBe 5IZE · UniProt P23456

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