Research workbench
Repoman-PP1A (protein phosphatase 1, alpha isoform) holoenzyme complex
Analyse Repoman-PP1A (protein phosphatase 1, alpha isoform) holoenzyme complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5IOH
- Type
- protein
- Length
- 650 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase PP1-alpha catalytic subunit; Cell division…
- EC
- 3.1.3.16
- UniProt
- P62136, Q69YH5
- Pockets
- 6 · best druggability 0.63
Structure
x-ray diffraction · 4 distinct chains · 31% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase PP1-alpha catalytic subunit (EC 3.1.3.16) | protein | 293 | 34% helix, 20% strand | P62136 |
| B | Cell division cycle-associated protein 2 | protein | 33 | 0% helix, 18% strand | Q69YH5 |
| C | SERINE/THREONINE-protein phosphatase PP1-alpha catalytic subunit (EC 3.1.3.16) | protein | 294 | 34% helix, 18% strand | P62136 |
| D | Cell division cycle-associated protein 2 | protein | 30 | 0% helix, 20% strand | Q69YH5 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 329 | 0.63 | 0.80 | 33 | empty |
| 2 | 149 | 0.55 | 0.81 | 26 | empty |
| 3 | 116 | 0.39 | 0.75 | 19 | empty |
| 4 | 88 | 0.37 | 0.75 | 20 | empty |
| 5 | 67 | 0.34 | 0.76 | 16 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1317 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 1249 Ų buried · 20 hydrogen bonds · protein-protein
- A–D · 333 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 271 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 5IOH · RepoMan-PP1a (protein phosphatase 1, alpha isoform) holoenzyme complex · the same entry in another collection · chain D against D, TM-score 1.00
- P62136 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase PP1-alpha… · a predicted model of the same protein · chain A against A, TM-score 1.00
- Q69YH5 · AlphaFold monomer V2.0 prediction for cell division cycle-associated protein 2 (Q69YH5) · a predicted model of the same protein · chain D against A, TM-score 0.27
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62136
- Every structure of UniProt Q69YH5
- Elsewhere: RCSB PDB 5IOH · PDBe 5IOH · UniProt P62136 · UniProt Q69YH5
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