Research workbench
Knob domain from adenovirus serotype 12 in complex with domain 1 of its cellular receptor car
Analyse Knob domain from adenovirus serotype 12 in complex with domain 1 of its… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1KAC
- Type
- protein
- Length
- 309 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (fiber knob protein); Protein (coxsackie virus and adenovirus receptor)
- UniProt
- P36711, P78310
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (fiber knob protein) | protein | 185 | 10% helix, 41% strand | P36711 |
| B | Protein (coxsackie virus and adenovirus receptor) | protein | 124 | 7% helix, 48% strand | P78310 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.43 | 0.75 | 23 | empty |
| 2 | 160 | 0.42 | 0.74 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 783 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1KAC · Knob domain from adenovirus serotype 12 in complex with domain 1 of its cellular receptor… · the same entry in another collection · chain A against A, TM-score 1.00
- P78310 · AlphaFold monomer V2.0 prediction for coxsackievirus and adenovirus receptor (P78310) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36711
- Every structure of UniProt P78310
- Elsewhere: RCSB PDB 1KAC · PDBe 1KAC · UniProt P36711 · UniProt P78310
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