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Human casein kinase 1 isoform delta apo (kinase domain)

Analyse Human casein kinase 1 isoform delta apo (kinase domain) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5IH4
Type: protein
Length: 287 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Casein kinase I isoform delta
EC: 2.7.11.1, 2.7.11.26
UniProt: P48730
Ligands: SRT, ZN, SO4
Pockets: 1 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Casein kinase I isoform delta (EC 2.7.11.1, 2.7.11.26)	protein	287	38% helix, 18% strand	P48730

Ligands and binding sites

SRT · S,R meso-tartaric acid · ligand · chains A
ZN · Zinc ion · metal · chains A
SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	120	0.56	0.84	24	empty

Compared structures

5IH4 · Human Casein Kinase 1 isoform delta apo (kinase domain) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P48730
Elsewhere: RCSB PDB 5IH4 · PDBe 5IH4 · UniProt P48730

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