Research workbench

X-ray crystallographic structure of a high affinity IGF2 antagonist (DOMAIN11 AB5 rhh) based on human IGF2R domain 11

Analyse X-ray crystallographic structure of a high affinity IGF2 antagonist (DOMAIN11… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5IEI
Type: protein
Length: 132 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cation-independent mannose-6-phosphate receptor
UniProt: P11717
Ligands: SO4

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cation-independent mannose-6-phosphate receptor	protein	132	5% helix, 46% strand	P11717

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A
EDO · 1,2-ethanediol · additive · 2 copies · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

5IEI · X-ray crystallographic structure of a high affinity IGF2 antagonist (Domain11 AB5 RHH)… · the same entry in another collection · chain A against A, TM-score 1.00
P11717 · AlphaFold monomer V2.0 prediction for cation-independent mannose-6-phosphate receptor… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11717
Elsewhere: RCSB PDB 5IEI · PDBe 5IEI · UniProt P11717

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.