UniProt P11717
Cation-independent mannose-6-phosphate receptor (P11717)
Cation-independent mannose-6-phosphate receptor (UniProt P11717): 36 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 24 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P11717
- Protein
- Cation-independent mannose-6-phosphate receptor
- Experimental structures
- 36
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 24 · 2 records with a druggable one
Structures
37 records of P11717 in the MolNFT archive: 36 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1E6F | Human MIR-receptor, repeat 11 | x-ray diffraction | A, B | — | — |
| 1E6F | Human mir-receptor, repeat 11 | x-ray diffraction | A, B | — | — |
| 1GP0 | Human IGF2R domain 11 | x-ray diffraction | A | — | — |
| 1GP0 | Human IGF2R domain 11 | x-ray diffraction | A | — | — |
| 1GP3 | Human IGF2R domain 11 | x-ray diffraction | A | — | — |
| 1GP3 | Human IGF2R domain 11 | x-ray diffraction | A | — | — |
| 1GQB | Human mir-receptor, repeat 11 | x-ray diffraction | A, B | — | — |
| 1GQB | Human mir-receptor, repeat 11 | x-ray diffraction | A, B | — | — |
| 1JPL | GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate… | x-ray diffraction | E, F, G, H | — | — |
| 1JPL | GGA3 vhs domain complexed with C-terminal peptide from cation-independent mannose 6-phosphate… | x-ray diffraction | E, F, G, H | — | — |
| 1JWG | VHS Domain of human GGA1 complexed with cation-independent M6PR C-terminal Peptide | x-ray diffraction | C, D | — | — |
| 1JWG | Vhs domain of human GGA1 complexed with cation-independent M6PR C-terminal peptide | x-ray diffraction | C, D | — | — |
| 1LF8 | Complex of GGA3-VHS Domain and CI-MPR C-terminal Phosphopeptide | x-ray diffraction | E, F, G, H | — | — |
| 1LF8 | Complex of GGA3-vhs domain and ci-mpr C-terminal phosphopeptide | x-ray diffraction | E, F, G, H | — | — |
| 2CNJ | NMR studies on the interaction of Insulin-Growth Factor II (IGF-II) with IGF2R domain 11 | solution nmr | D | — | — |
| 2CNJ | NMR studies on the interaction of insulin-growth factor II ( igf-II) with IGF2R domain 11 | solution nmr | D | — | — |
| 2V5N | Structure of human IGF2R domains 11-12 | x-ray diffraction | A | — | — |
| 2V5N | Structure of human IGF2R domains 11-12 | x-ray diffraction | A | — | — |
| 2V5O | Structure of human IGF2R domains 11-14 | x-ray diffraction | A | — | — |
| 2V5O | Structure of human IGF2R domains 11-14 | x-ray diffraction | A | — | — |
| 2V5P | Complex structure of human IGF2R domains 11-13 bound to igf-II | x-ray diffraction | A, B | — | — |
| 2V5P | Complex structure of human IGF2R domains 11-13 bound to igf-II | x-ray diffraction | A, B | — | — |
| 5IEI | X-ray crystallographic structure of a high affinity IGF2 antagonist (Domain11 AB5 RHH) based on… | x-ray diffraction | A | SO4 | — |
| 5IEI | X-ray crystallographic structure of a high affinity IGF2 antagonist (DOMAIN11 AB5 rhh) based on… | x-ray diffraction | A | — | — |
| 6N5X | Crystal structure of the SNX5 PX domain in complex with the CI-MPR (space group P212121 - Form 1) | x-ray diffraction | A | JEF | — |
| 6N5X | Crystal structure of the SNX5 px domain in complex with the ci-mpr (space group P212121 - form 1) | x-ray diffraction | A | JEF | — |
| 6N5Y | Crystal structure of the SNX5 PX domain in complex with the CI-MPR (space group P212121 - Form 1) | x-ray diffraction | A | — | — |
| 6N5Y | Crystal structure of the SNX5 px domain in complex with the ci-mpr (space group P212121 - form 1) | x-ray diffraction | A | — | — |
| 6P8I | N-terminal 5 domains of IGFIIR | x-ray diffraction | A | NAG | — |
| 6P8I | N-terminal 5 domains of igfiir | x-ray diffraction | A | NAG | — |
| 6V02 | N-terminal 5 domains of ci-mpr | x-ray diffraction | A | NAG | — |
| 6Z30 | Human cation-independent mannose 6-phosphate/ IGF2 receptor domains 9-10 | x-ray diffraction | A | NAG, BMA, MAN | 1 (best 0.46) |
| 6Z30 | Human cation-independent mannose 6-phosphate/ IGF2 receptor domains 9- 10 | x-ray diffraction | A | NAG, BMA, MAN | — |
| 6Z31 | Human cation-independent mannose 6-phosphate/ IGF2 receptor domain 8 | x-ray diffraction | A, B | CL, NA | — |
| 6Z32 | Human cation-independent mannose 6-PHOSPHATE/IGF2 receptor domains 7- 11 | x-ray diffraction | A, B | NAG, BMA, MAN, SO4 | — |
| 8AFZ | Architecture of the ESCPE-1 membrane coat | electron microscopy | C | — | 3 (best 0.63) |
| P11717 | AlphaFold monomer V2.0 prediction for cation-independent mannose-6-phosphate receptor (P11717) | predicted | A | — | 20 (best 0.84) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 6 records
- BMA · beta-D-mannopyranose · in 3 records
- MAN · alpha-D-mannopyranose · in 3 records
- JEF · O-(O-(2-aminopropyl)-O'-(2-methoxyethyl)polypropylene glycol 500) · in 2 records
- SO4 · Sulfate ion · in 2 records
- CL · Chloride ion · in 1 record
- NA · Sodium ion · in 1 record
Experiment against prediction
- 1E6F chain A against the predicted model P11717: TM-score 0.97, RMSD 0.85 Å
- 1E6F chain A against the predicted model P11717: TM-score 0.97, RMSD 0.85 Å
- 1GP3 chain A against the predicted model P11717: TM-score 0.96, RMSD 0.92 Å
- 1GP3 chain A against the predicted model P11717: TM-score 0.96, RMSD 0.92 Å
- 1GQB chain B against the predicted model P11717: TM-score 0.96, RMSD 0.96 Å
- 1GQB chain B against the predicted model P11717: TM-score 0.96, RMSD 0.96 Å
- 1GP0 chain A against the predicted model P11717: TM-score 0.96, RMSD 0.97 Å
- 1GP0 chain A against the predicted model P11717: TM-score 0.96, RMSD 0.97 Å
- 1GQB chain A against the predicted model P11717: TM-score 0.96, RMSD 1.03 Å
- 1GQB chain A against the predicted model P11717: TM-score 0.96, RMSD 1.03 Å
Elsewhere
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