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Structure of the cholesterol and lutein-binding domain of human STARD3 at 1.74A

Analyse Structure of the cholesterol and lutein-binding domain of human STARD3 at 1.74A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
5I9J
Type
protein
Length
214 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Star-related lipid transfer protein 3
UniProt
Q14849
Ligands
SO4
Pockets
2 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 37% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AStar-related lipid transfer protein 3protein21432% helix, 37% strandQ14849

Ligands and binding sites

  • SO4 · Sulfate ion · ion · chains A
  • EDO · 1,2-ethanediol · additive · 3 copies · chains A
  • TLA · L(+)-tartaric acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12770.820.9455EDO
2580.310.7618EDO

Compared structures

  • 5I9J · Structure of the cholesterol and lutein-binding domain of human STARD3 at 1.74A · the same entry in another collection · chain A against A, TM-score 1.00
  • Q14849 · AlphaFold monomer V2.0 prediction for star-related lipid transfer protein 3 (Q14849) · a predicted model of the same protein · chain A against A, TM-score 1.00

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