Centrosomin-motif 2 (CM2) domain of drosophila melanogaster centrosomin (cnn)

Structure

x-ray diffraction · 2 distinct chains · 92% helix, 0% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 2 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

6 interfaces between chains.

• B–D · 941 Ų buried · 3 hydrogen bonds · protein-protein
• A–C · 929 Ų buried · 3 hydrogen bonds · protein-protein
• B–C · 907 Ų buried · 2 hydrogen bonds · protein-protein
• A–D · 883 Ų buried · 1 hydrogen bond · protein-protein
• A–B · 631 Ų buried · 7 hydrogen bonds · protein-protein

Compared structures

• 5I7C · Centrosomin-motif 2 (CM2) domain of Drosophila melanogaster Centrosomin (Cnn) · the same entry in another collection · chain D against D, TM-score 1.00
• P54623 · AlphaFold monomer V2.0 prediction for centrosomin (P54623) · a predicted model of the same protein · chain C against A, TM-score 0.86

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P54623
• Elsewhere: RCSB PDB 5I7C · PDBe 5I7C · UniProt P54623