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Solution structure of the lipoic acid-bearing domain of the E2 component of human, mitochondrial branched-chain alpha-ketoacid dehydrogenase

Analyse Solution structure of the lipoic acid-bearing domain of the E2 component of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1K8M
Type: protein
Length: 87 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: E2 component of branched-chain alpha-ketoacid dehydrogenase
EC: 2.3.1.-
UniProt: P11182
Pockets: 1 · best druggability 0.53

Structure

solution nmr · 1 distinct chain · 0% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	E2 component of branched-chain alpha-ketoacid dehydrogenase (EC 2.3.1.-)	protein	87	0% helix, 38% strand	P11182

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	127	0.53	0.81	18	empty

Compared structures

1K8M · Solution Structure of the Lipoic Acid-Bearing Domain of the E2 component of Human… · the same entry in another collection · chain A against A, TM-score 1.00
P11182 · AlphaFold monomer V2.0 prediction for lipoamide acyltransferase component of… · a predicted model of the same protein · chain A against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11182
Elsewhere: RCSB PDB 1K8M · PDBe 1K8M · UniProt P11182

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