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FABP4 in complex with 6-chloro-2-isopropyl-4-(3-isopropyl-phenyl)- quinoline-3-carboxylic acid

Analyse FABP4 in complex with 6-chloro-2-isopropyl-4-(3-isopropyl-phenyl)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5HZ6
Type: protein
Length: 131 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fatty acid-binding protein, adipocyte
UniProt: P15090
Ligands: 65Y
Pockets: 1 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 13% helix, 58% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fatty acid-binding protein, adipocyte	protein	131	13% helix, 58% strand	P15090

Ligands and binding sites

65Y · 6-Chloro-2-isopropyl-4-(3-isopropyl-phenyl)-quinoline-3-carboxylic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	313	0.84	0.94	36	65Y

Compared structures

5HZ6 · FABP4 in complex with 6-Chloro-2-isopropyl-4-(3-isopropyl-phenyl)-quinoline-3-carboxylic… · the same entry in another collection · chain A against A, TM-score 1.00
P15090 · AlphaFold monomer V2.0 prediction for fatty acid-binding protein, adipocyte (P15090) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15090
Elsewhere: RCSB PDB 5HZ6 · PDBe 5HZ6 · UniProt P15090

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