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Crystal structure of procaspase-7

Analyse Crystal structure of procaspase-7 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1K88
Type: protein
Length: 461 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Procaspase-7
EC: 3.4.22.-
UniProt: P55210
Pockets: 5 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Procaspase-7 (EC 3.4.22.-)	protein	227	31% helix, 21% strand	P55210
B	Procaspase-7 (EC 3.4.22.-)	protein	234	29% helix, 19% strand	P55210

Pockets

5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	111	0.65	0.89	26	empty
2	271	0.57	0.77	38	empty
3	235	0.56	0.78	39	empty
4	159	0.55	0.81	28	empty
5	130	0.49	0.80	24	empty

Interfaces

1 interface between chains.

A–B · 1543 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

1K88 · Crystal structure of procaspase-7 · the same entry in another collection · chain A against A, TM-score 1.00
P55210 · AlphaFold monomer V2.0 prediction for caspase-7 (P55210) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P55210
Elsewhere: RCSB PDB 1K88 · PDBe 1K88 · UniProt P55210

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