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Structure of hcmv small terminase nls bound to importin alpha
Analyse Structure of hcmv small terminase nls bound to importin alpha in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5HUY
- Type
- protein
- Length
- 439 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; Hcmv small terminase
- UniProt
- P52293
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 3 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Importin subunit alpha-1 | protein | 423 | 75% helix, 0% strand | P52293 |
| B | Hcmv small terminase | protein | 7 | 0% helix, 0% strand | — |
| A | Hcmv small terminase | protein | 9 | 0% helix, 0% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.46 | 0.82 | 13 | empty |
| 2 | 52 | 0.35 | 0.79 | 17 | empty |
Interfaces
2 interfaces between chains.
- C–A · 782 Ų buried · 22 hydrogen bonds · protein-protein
- C–B · 525 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 5HUY · Structure of HCMV Small Terminase NLS bound to importin alpha · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Elsewhere: RCSB PDB 5HUY · PDBe 5HUY · UniProt P52293
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