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Structure of HSV-1 large terminase nls bound to importin alpha

Analyse Structure of HSV-1 large terminase nls bound to importin alpha in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5HUW
Type: protein
Length: 439 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-1; HSV1 large terminase nls
UniProt: P52293
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 3 distinct chains · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Importin subunit alpha-1	protein	423	74% helix, 0% strand	P52293
A	HSV1 large terminase nls	protein	10	0% helix, 0% strand	—
B	HSV1 large terminase nls	protein	6	0% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	59	0.42	0.81	13	empty
2	59	0.31	0.76	17	empty

Interfaces

2 interfaces between chains.

C–A · 751 Å² buried · 19 hydrogen bonds · protein-protein
C–B · 553 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

5HUW · Structure of HSV-1 Large Terminase NLS bound to importin alpha · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Elsewhere: RCSB PDB 5HUW · PDBe 5HUW · UniProt P52293

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