Research workbench
Phosphatase domain of PP5 bound to a phosphomimetic CDC37 substrate peptide
Analyse Phosphatase domain of PP5 bound to a phosphomimetic CDC37 substrate peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5HPE
- Type
- protein
- Length
- 326 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein phosphatase 5,HSP90 co-chaperone CDC37
- EC
- 3.1.3.16
- UniProt
- P53041, K7EJ06
- Ligands
- NCO, MN
- Pockets
- 1 · best druggability 0.27
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein phosphatase 5,HSP90 co-chaperone CDC37 (EC 3.1.3.16) | protein | 326 | 33% helix, 20% strand | P53041, K7EJ06 |
Ligands and binding sites
- NCO · Cobalt hexammine(iii) · ligand · 2 copies · chains A
- MN · Manganese (II) ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 53 | 0.27 | 0.73 | 9 | empty |
Compared structures
- 5HPE · Phosphatase domain of PP5 bound to a phosphomimetic Cdc37 substrate peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P53041 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 5 (P53041) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53041
- Every structure of UniProt K7EJ06
- Elsewhere: RCSB PDB 5HPE · PDBe 5HPE · UniProt P53041 · UniProt K7EJ06
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.