Research workbench

Mouse importin alpha: dengue 2 NS5 C-terminal nls peptide complex

Analyse Mouse importin alpha: dengue 2 NS5 C-terminal nls peptide complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5HHG
Type: protein
Length: 440 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed RNA polymerase NS5; Importin subunit alpha-1
EC: 2.1.1.56, 2.1.1.57, 2.7.7.48
UniProt: P12823, P52293
Pockets: 2 · best druggability 0.48

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	RNA-directed RNA polymerase NS5 (EC 2.1.1.56, 2.1.1.57, 2.7.7.48)	protein	13	0% helix, 0% strand	P12823
E	Importin subunit alpha-1	protein	427	74% helix, 0% strand	P52293

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.48	0.83	13	empty
2	83	0.32	0.74	19	empty

Interfaces

1 interface between chains.

C–E · 1053 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

5HHG · Mouse importin alpha: Dengue 2 NS5 C-terminal NLS peptide complex · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12823
Every structure of UniProt P52293
Elsewhere: RCSB PDB 5HHG · PDBe 5HHG · UniProt P12823 · UniProt P52293

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