Research workbench
Pentameric ligand-gated ion channel elic mutant P254G
Analyse Pentameric ligand-gated ion channel elic mutant P254G in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5HEO
- Type
- protein
- Length
- 3,070 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-aminobutyric-acid receptor subunit beta-1
- UniProt
- E0SJQ4
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Gamma-aminobutyric-acid receptor subunit beta-1 | protein | 307 | 36% helix, 33% strand | E0SJQ4 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 182 | 0.83 | 0.97 | 24 | empty |
| 2 | 178 | 0.83 | 0.97 | 22 | empty |
| 3 | 914 | 0.82 | 0.84 | 96 | empty |
| 4 | 921 | 0.82 | 0.83 | 92 | empty |
| 5 | 865 | 0.81 | 0.84 | 92 | empty |
Interfaces
22 interfaces between chains.
- B–C · 2624 Ų buried · 27 hydrogen bonds · protein-protein
- G–H · 2604 Ų buried · 28 hydrogen bonds · protein-protein
- C–D · 2598 Ų buried · 25 hydrogen bonds · protein-protein
- H–I · 2597 Ų buried · 27 hydrogen bonds · protein-protein
- F–J · 2590 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 5HEO · Pentameric ligand-gated ion channel ELIC mutant P254G · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E0SJQ4
- Elsewhere: RCSB PDB 5HEO · PDBe 5HEO · UniProt E0SJQ4
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