Research workbench
Pentameric ligand-gated ion channel glic mutant P246G
Analyse Pentameric ligand-gated ion channel glic mutant P246G in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5HEG
- Type
- protein
- Length
- 1,550 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proton-gated ion channel
- UniProt
- Q7NDN8
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Proton-gated ion channel | protein | 310 | 35% helix, 33% strand | Q7NDN8 |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 726 | 0.86 | 0.89 | 95 | empty |
| 2 | 236 | 0.79 | 0.92 | 39 | empty |
| 3 | 244 | 0.79 | 0.91 | 38 | empty |
| 4 | 209 | 0.78 | 0.92 | 34 | empty |
| 5 | 172 | 0.76 | 0.92 | 26 | empty |
Interfaces
10 interfaces between chains.
- A–B · 2222 Ų buried · 17 hydrogen bonds · protein-protein
- D–E · 2212 Ų buried · 16 hydrogen bonds · protein-protein
- A–E · 2199 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 2197 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 2179 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NDN8
- Elsewhere: RCSB PDB 5HEG · PDBe 5HEG · UniProt Q7NDN8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.