Research workbench
Crystal structure of proliferating cell nuclear antigen from leishmania donovani at 2.95 a resolution
Analyse Crystal structure of proliferating cell nuclear antigen from leishmania… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5HAC
- Type
- protein
- Length
- 1,562 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proliferating cell nuclear antigen
- UniProt
- B5TV91
- Pockets
- 11 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Proliferating cell nuclear antigen | protein | 260 | 18% helix, 42% strand | B5TV91 |
| B, D, F | Proliferating cell nuclear antigen | protein | 261 | 18% helix, 43% strand | B5TV91 |
| E | Proliferating cell nuclear antigen | protein | 259 | 18% helix, 44% strand | B5TV91 |
Pockets
11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 816 | 0.72 | 0.77 | 86 | empty |
| 2 | 545 | 0.63 | 0.75 | 57 | empty |
| 3 | 212 | 0.50 | 0.76 | 33 | empty |
| 4 | 75 | 0.45 | 0.81 | 12 | empty |
| 5 | 57 | 0.37 | 0.79 | 12 | empty |
Interfaces
11 interfaces between chains.
- A–B · 732 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 707 Ų buried · 13 hydrogen bonds · protein-protein
- D–E · 706 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 690 Ų buried · 13 hydrogen bonds · protein-protein
- D–F · 685 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5HAC · Crystal structure of Proliferating Cell Nuclear Antigen from Leishmania donovani at 2.95… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B5TV91
- Elsewhere: RCSB PDB 5HAC · PDBe 5HAC · UniProt B5TV91
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.