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Crystal structure of a repeat protein with four protein a repeat module
Analyse Crystal structure of a repeat protein with four protein a repeat module in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5H7A
- Type
- protein
- Length
- 2,252 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin G-binding protein a
- UniProt
- P38507
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 4 distinct chains · 82% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, B | Immunoglobulin G-binding protein a | protein | 189 | 82% helix, 0% strand | P38507 |
| A, D, F, G, I | Immunoglobulin G-binding protein a | protein | 188 | 82% helix, 0% strand | P38507 |
| E, H, J, K | Immunoglobulin G-binding protein a | protein | 187 | 83% helix, 0% strand | P38507 |
| L | Immunoglobulin G-binding protein a | protein | 186 | 82% helix, 0% strand | P38507 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1081 | 0.82 | 0.83 | 121 | empty |
| 2 | 1046 | 0.81 | 0.82 | 116 | empty |
| 3 | 1083 | 0.81 | 0.82 | 105 | empty |
| 4 | 404 | 0.61 | 0.76 | 39 | empty |
| 5 | 236 | 0.60 | 0.80 | 35 | empty |
Interfaces
22 interfaces between chains.
- F–J · 780 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 772 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 772 Ų buried · 6 hydrogen bonds · protein-protein
- I–K · 768 Ų buried · 10 hydrogen bonds · protein-protein
- J–L · 735 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 5H7A · Crystal structure of a repeat protein with four Protein A repeat module · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38507
- Elsewhere: RCSB PDB 5H7A · PDBe 5H7A · UniProt P38507
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