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Crystal structure of the darpin-protein a fusion protein

Analyse Crystal structure of the darpin-protein a fusion protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5H76
Type: protein
Length: 591 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DARPIN,IMMUNOGLOBULIN G-binding protein a
UniProt: P38507
Pockets: 5 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 60% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	DARPIN,IMMUNOGLOBULIN G-binding protein a	protein	197	60% helix, 0% strand	P38507

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	603	0.74	0.80	67	empty
2	620	0.73	0.80	74	empty
3	87	0.40	0.77	14	empty
4	54	0.39	0.81	13	empty
5	92	0.36	0.74	16	empty

Interfaces

2 interfaces between chains.

A–B · 653 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 631 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

5H76 · Crystal structure of the DARPin-Protein A fusion protein · the same entry in another collection · chain A against A, TM-score 1.00
P38507 · AlphaFold monomer V2.0 prediction for immunoglobulin G-binding protein a (P38507) · a predicted model of the same protein · chain A against A, TM-score 0.26

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38507
Elsewhere: RCSB PDB 5H76 · PDBe 5H76 · UniProt P38507

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