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Structure of acetyl-coenzyme a synthase alpha subunit C-terminal domain F598H mutant
Analyse Structure of acetyl-coenzyme a synthase alpha subunit C-terminal domain F598H… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5H6W
- Type
- protein
- Length
- 504 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carbon monoxide DEHYDROGENASE/ACETYL-CoA synthase subunit alpha
- EC
- 2.3.1.169
- UniProt
- P27988
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Carbon monoxide DEHYDROGENASE/ACETYL-CoA synthase subunit alpha (EC 2.3.1.169) | protein | 125 | 46% helix, 16% strand | P27988 |
| B, D | Carbon monoxide DEHYDROGENASE/ACETYL-CoA synthase subunit alpha (EC 2.3.1.169) | protein | 127 | 46% helix, 16% strand | P27988 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 153 | 0.66 | 0.86 | 31 | empty |
| 2 | 164 | 0.63 | 0.84 | 27 | empty |
| 3 | 346 | 0.53 | 0.74 | 36 | empty |
| 4 | 118 | 0.50 | 0.80 | 27 | empty |
Interfaces
4 interfaces between chains.
- C–D · 588 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 572 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 409 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 375 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5H6W · Structure of acetyl-Coenzyme A synthase Alpha subunit C-terminal domain F598H mutant · the same entry in another collection · chain D against D, TM-score 1.00
- P27988 · AlphaFold monomer V2.0 prediction for carbon monoxide DEHYDROGENASE/ACETYL-CoA synthase… · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27988
- Elsewhere: RCSB PDB 5H6W · PDBe 5H6W · UniProt P27988
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