Research workbench
TNIP2-ub complex, C2 form
Analyse TNIP2-ub complex, C2 form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5H07
- Type
- protein
- Length
- 367 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polyubiquitin-C; TNFAIP3-interacting protein 2
- UniProt
- P0CG48, Q8NFZ5
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 3 distinct chains · 50% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polyubiquitin-C | protein | 223 | 21% helix, 34% strand | P0CG48 |
| D | TNFAIP3-interacting protein 2 | protein | 78 | 92% helix, 0% strand | Q8NFZ5 |
| C | TNFAIP3-interacting protein 2 | protein | 66 | 95% helix, 0% strand | Q8NFZ5 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.44 | 0.74 | 24 | empty |
| 2 | 74 | 0.30 | 0.73 | 14 | empty |
Interfaces
3 interfaces between chains.
- D–C · 1789 Ų buried · 17 hydrogen bonds · protein-protein
- A–D · 719 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 495 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0CG48
- Every structure of UniProt Q8NFZ5
- Elsewhere: RCSB PDB 5H07 · PDBe 5H07 · UniProt P0CG48 · UniProt Q8NFZ5
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