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Crystal structure of helicobacter pylori beta clamp in complex with carprofen

Analyse Crystal structure of helicobacter pylori beta clamp in complex with carprofen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5FXT
Type: protein
Length: 374 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA polymerase III subunit beta
EC: 2.7.7.7
UniProt: O25242
Ligands: 0LA
Pockets: 2 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 21% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA polymerase III subunit beta (EC 2.7.7.7)	protein	374	21% helix, 40% strand	O25242

Ligands and binding sites

0LA · (2S)-2-(6-chloro-9H-carbazol-2-yl)propanoic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	160	0.51	0.79	25	empty
2	50	0.25	0.73	15	empty

Compared structures

5FXT · Crystal Structure of Helicobacter pylori beta clamp in complex with Carprofen · the same entry in another collection · chain A against A, TM-score 1.00
O25242 · AlphaFold monomer V2.0 prediction for beta sliding clamp (O25242) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O25242
Elsewhere: RCSB PDB 5FXT · PDBe 5FXT · UniProt O25242

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