Research workbench
Structure of the BCR-abl oncoprotein oligomerization domain
Analyse Structure of the BCR-abl oncoprotein oligomerization domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1K1F
- Type
- protein
- Length
- 527 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Breakpoint cluster region protein
- EC
- 2.7.1.-
- UniProt
- P11274
- Pockets
- 8 · best druggability 0.80
Structure
x-ray diffraction · 5 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, F | Breakpoint cluster region protein (EC 2.7.1.-) | protein | 67 | 72% helix, 0% strand | P11274 |
| D | Breakpoint cluster region protein (EC 2.7.1.-) | protein | 66 | 74% helix, 2% strand | P11274 |
| E | Breakpoint cluster region protein (EC 2.7.1.-) | protein | 65 | 72% helix, 0% strand | P11274 |
| G | Breakpoint cluster region protein (EC 2.7.1.-) | protein | 65 | 66% helix, 0% strand | P11274 |
| H | Breakpoint cluster region protein (EC 2.7.1.-) | protein | 63 | 75% helix, 0% strand | P11274 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 985 | 0.80 | 0.81 | 66 | empty |
| 2 | 113 | 0.67 | 0.90 | 23 | empty |
| 3 | 65 | 0.58 | 0.89 | 18 | empty |
| 4 | 150 | 0.56 | 0.82 | 22 | empty |
| 5 | 91 | 0.48 | 0.81 | 19 | empty |
Interfaces
22 interfaces between chains.
- C–D · 2267 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 2179 Ų buried · 4 hydrogen bonds · protein-protein
- E–F · 2104 Ų buried · 3 hydrogen bonds · protein-protein
- G–H · 2004 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 710 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 22 modified (engineered).
Compared structures
- 1K1F · Structure of the Bcr-Abl Oncoprotein Oligomerization domain · the same entry in another collection · chain H against H, TM-score 1.00
- P11274 · AlphaFold monomer V2.0 prediction for breakpoint cluster region protein (P11274) · a predicted model of the same protein · chain H against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11274
- Elsewhere: RCSB PDB 1K1F · PDBe 1K1F · UniProt P11274
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