UniProt P11274
Breakpoint cluster region protein (P11274)
Breakpoint cluster region protein (UniProt P11274), EC 2.7.11.1: 9 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P11274
- Protein
- Breakpoint cluster region protein
- EC
- 2.7.11.1
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 1 · 1 record with a druggable one
Structures
10 records of P11274 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1K1F | Structure of the Bcr-Abl Oncoprotein Oligomerization domain | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1K1F | Structure of the BCR-abl oncoprotein oligomerization domain | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2AIN | Solution structure of the AF-6 PDZ domain complexed with the C-terminal peptide from the Bcr protein | solution nmr | B | — | — |
| 2AIN | Solution structure of the af-6 PDZ domain complexed with the C- terminal peptide from the BCR… | solution nmr | B | — | — |
| 5N6R | Solution structure of the Dbl-homology domain of Bcr-Abl | solution nmr | A | — | — |
| 5N6R | Solution structure of the dbl-homology domain of BCR-abl | solution nmr | A | — | — |
| 5N7E | Crystal structure of the Dbl-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-DH_4). | x-ray diffraction | B | — | 1 (best 0.72) |
| 5N7E | Crystal structure of the dbl-homology domain of BCR-abl in complex with monobody MB(BCR-DH_4). | x-ray diffraction | B | — | — |
| 5OC7 | Crystal structure of the pleckstrin-homology domain of BCR-abl in complex with monobody… | x-ray diffraction | D, A | IP2 | — |
| P11274 | AlphaFold monomer V2.0 prediction for breakpoint cluster region protein (P11274) | predicted | A | — | — |
Ligands
- IP2 · D-myo-inositol-4,5-bisphosphate · in 1 record
Experiment against prediction
- 5N7E chain B against the predicted model P11274: TM-score 0.97, RMSD 1.10 Å
- 5N7E chain B against the predicted model P11274: TM-score 0.97, RMSD 1.10 Å
- 5OC7 chain A against the predicted model P11274: TM-score 0.92, RMSD 1.59 Å
- 5OC7 chain D against the predicted model P11274: TM-score 0.89, RMSD 2.03 Å
- 2AIN chain B against the predicted model P11274: TM-score 0.80, RMSD 0.25 Å
- 2AIN chain B against the predicted model P11274: TM-score 0.80, RMSD 0.25 Å
- 1K1F chain H against the predicted model P11274: TM-score 0.80, RMSD 1.52 Å
- 1K1F chain H against the predicted model P11274: TM-score 0.80, RMSD 1.52 Å
- 1K1F chain B against the predicted model P11274: TM-score 0.77, RMSD 1.89 Å
- 1K1F chain B against the predicted model P11274: TM-score 0.77, RMSD 1.89 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.