Research workbench
MU2 adaptin subunit of the AP2 adaptor (C-terminal domain) complexed with integrin ALPHA4 internalisation peptide qyksilqe
Analyse MU2 adaptin subunit of the AP2 adaptor (C-terminal domain) complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5FPI
- Type
- protein
- Length
- 264 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ap-2 complex subunit mu; Integrin alpha-4 subunit
- UniProt
- P84092, Q8IU71
- Pockets
- 3 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 56% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ap-2 complex subunit mu | protein | 258 | 1% helix, 57% strand | P84092 |
| B | Integrin alpha-4 subunit | protein | 6 | 0% helix, 33% strand | Q8IU71 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 94 | 0.47 | 0.80 | 19 | empty |
| 2 | 119 | 0.43 | 0.77 | 20 | empty |
| 3 | 93 | 0.37 | 0.75 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 454 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 5FPI · Mu2 adaptin subunit of the AP2 adaptor (C-terminal domain) complexed with Integrin alpha4… · the same entry in another collection · chain A against A, TM-score 1.00
- P84092 · AlphaFold monomer V2.0 prediction for ap-2 complex subunit mu (P84092) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P84092
- Every structure of UniProt Q8IU71
- Elsewhere: RCSB PDB 5FPI · PDBe 5FPI · UniProt P84092 · UniProt Q8IU71
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