Research workbench
Crystal structure of the endonuclease from the pa subunit of influenza B virus bound to the PB2 subunit nls peptide
Analyse Crystal structure of the endonuclease from the pa subunit of influenza B virus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5FML
- Type
- protein
- Length
- 215 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- PB2 subunit of influenza B polymerase; Pa subunit of influenza B polymerase
- UniProt
- Q5V8X3, Q5V8Z9
- Ligands
- MG
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | PB2 subunit of influenza B polymerase | protein | 19 | 89% helix, 0% strand | Q5V8X3 |
| B | Pa subunit of influenza B polymerase | protein | 196 | 47% helix, 16% strand | Q5V8Z9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 238 | 0.55 | 0.77 | 26 | MG |
| 2 | 76 | 0.31 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 755 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 5FML · Crystal structure of the endonuclease from the PA subunit of influenza B virus bound to… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5V8X3
- Every structure of UniProt Q5V8Z9
- Elsewhere: RCSB PDB 5FML · PDBe 5FML · UniProt Q5V8X3 · UniProt Q5V8Z9
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