Research workbench
Crystal structure of the MYOMESIN:OBSCURIN-like-1 complex
Analyse Crystal structure of the MYOMESIN:OBSCURIN-like-1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5FM5
- Type
- protein
- Length
- 441 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myomesin-1; Obscurin-like-1
- UniProt
- P52179, O75147
- Pockets
- 6 · best druggability 0.60
Structure
x-ray diffraction · 3 distinct chains · 4% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| M, N | Myomesin-1 | protein | 123 | 7% helix, 44% strand | P52179 |
| O | Obscurin-like-1 | protein | 97 | 3% helix, 54% strand | O75147 |
| P | Obscurin-like-1 | protein | 98 | 3% helix, 51% strand | O75147 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 361 | 0.60 | 0.77 | 31 | empty |
| 2 | 220 | 0.56 | 0.78 | 31 | empty |
| 3 | 155 | 0.47 | 0.76 | 18 | empty |
| 4 | 167 | 0.45 | 0.75 | 20 | empty |
| 5 | 118 | 0.39 | 0.75 | 28 | empty |
Interfaces
6 interfaces between chains.
- M–P · 1191 Ų buried · 23 hydrogen bonds · protein-protein
- N–O · 1187 Ų buried · 26 hydrogen bonds · protein-protein
- N–P · 1124 Ų buried · 14 hydrogen bonds · protein-protein
- M–O · 1094 Ų buried · 13 hydrogen bonds · protein-protein
- O–P · 311 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 5FM5 · Crystal structure of the myomesin:obscurin-like-1 complex · the same entry in another collection · chain M against M, TM-score 1.00
- O75147 · AlphaFold monomer V2.0 prediction for obscurin-like protein 1 (O75147) · a predicted model of the same protein · chain O against A, TM-score 0.92
- P52179 · AlphaFold monomer V2.0 prediction for myomesin-1 (P52179) · a predicted model of the same protein · chain M against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52179
- Every structure of UniProt O75147
- Elsewhere: RCSB PDB 5FM5 · PDBe 5FM5 · UniProt P52179 · UniProt O75147
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