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Crystal structure of a soluble form of CLIC1. an intracellular chloride ion channel

Analyse Crystal structure of a soluble form of CLIC1. an intracellular chloride ion… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1K0O
Type: protein
Length: 438 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Chloride intracellular channel protein 1
UniProt: O00299
Pockets: 2 · best druggability 0.49

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Chloride intracellular channel protein 1	protein	225	49% helix, 11% strand	O00299
B	Chloride intracellular channel protein 1	protein	213	50% helix, 9% strand	O00299

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	234	0.49	0.75	27	empty
2	68	0.28	0.73	20	empty

Interfaces

1 interface between chains.

A–B · 190 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

1K0O · Crystal structure of a soluble form of CLIC1. An intracellular chloride ion channel · the same entry in another collection · chain A against A, TM-score 1.00
O00299 · AlphaFold monomer V2.0 prediction for chloride intracellular channel protein 1 (O00299) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00299
Elsewhere: RCSB PDB 1K0O · PDBe 1K0O · UniProt O00299

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