Research workbench
Crystal structure of IMPASE/NADP phosphatase complexed with NADP and CA2+ at pH 7.0
Analyse Crystal structure of IMPASE/NADP phosphatase complexed with NADP and CA2+ at pH… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5EYH
- Type
- protein
- Length
- 520 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inositol monophosphatase
- EC
- 3.1.3.25
- UniProt
- A0A0D6HL44
- Ligands
- NAP, CA
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inositol monophosphatase (EC 3.1.3.25) | protein | 262 | 34% helix, 26% strand | A0A0D6HL44 |
| B | Inositol monophosphatase (EC 3.1.3.25) | protein | 258 | 35% helix, 26% strand | A0A0D6HL44 |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, B
- CA · Calcium ion · metal · 5 copies · chains A, B
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 508 | 0.71 | 0.81 | 37 | CA, NAP |
| 2 | 101 | 0.68 | 0.92 | 32 | empty |
| 3 | 347 | 0.60 | 0.77 | 35 | CA, NAP |
| 4 | 95 | 0.31 | 0.72 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1436 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 5EYH · Crystal Structure of IMPase/NADP phosphatase complexed with NADP and Ca2+ at pH 7.0 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0D6HL44
- Elsewhere: RCSB PDB 5EYH · PDBe 5EYH · UniProt A0A0D6HL44
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.