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Structure III of intact U2AF65 recognizing the 3' splice site signal

Analyse Structure III of intact U2AF65 recognizing the 3' splice site signal in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
5EV3
Type
protein + RNA
Length
204 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Splicing factor U2AF 65 kda subunit; DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU)P*UP*…
UniProt
P26368
Pockets
1 · best druggability 0.28

Structure

x-ray diffraction · 2 distinct chains · 25% helix, 28% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ASplicing factor U2AF 65 kda subunitprotein19625% helix, 28% strandP26368
BDNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU)P*UP*U)- 3')rna8——

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1590.280.7415empty

Interfaces

1 interface between chains.

  • A–B · 1197 Ų buried · 44 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 1 modified (nucleotide modification).

Compared structures

  • 5EV3 · Structure III of Intact U2AF65 Recognizing the 3' Splice Site Signal · the same entry in another collection · chain A against A, TM-score 1.00
  • P26368 · AlphaFold monomer V2.0 prediction for splicing factor U2AF 65 kda subunit (P26368) · a predicted model of the same protein · chain A against A, TM-score 0.84

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