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Human GLUT1 in complex with cytochalasin B

Analyse Human GLUT1 in complex with cytochalasin B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5EQI
Type: protein
Length: 447 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Solute carrier family 2, facilitated glucose transporter member 1
UniProt: P11166
Ligands: 5RH
Pockets: 4 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Solute carrier family 2, facilitated glucose transporter member 1	protein	447	75% helix, 0% strand	P11166

Ligands and binding sites

5RH · Cytochalasin B · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	871	0.79	0.81	61	5RH
2	142	0.44	0.76	27	empty
3	56	0.36	0.78	12	empty
4	53	0.36	0.79	11	empty

Compared structures

5EQI · Human GLUT1 in complex with Cytochalasin B · the same entry in another collection · chain A against A, TM-score 1.00
P11166 · AlphaFold monomer V2.0 prediction for solute carrier family 2, facilitated glucose… · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11166
Elsewhere: RCSB PDB 5EQI · PDBe 5EQI · UniProt P11166

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