Co-crystal structure of EIF4E with nucleotide mimetic inhibitor.

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 25% strand (DSSP).

Ligands and binding sites

• 5O8 · ~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[2-azanyl-6-oxidanylidene-7-(phenylmethyl)-1~{H}-purin-7-ium-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-1,1,1-tris(fluoranyl)methanesulfonamide · ligand · chains A
• SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 706 Ų buried · 10 hydrogen bonds · protein-protein

Compared structures

• 5EI3 · Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. · the same entry in another collection · chain A against A, TM-score 1.00
• P06730 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P06730) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P06730
• Elsewhere: RCSB PDB 5EI3 · PDBe 5EI3 · UniProt P06730